Therapeutic roles of natural remedies in combating hereditary ataxia: A systematic review

Abstract Background Hereditary ataxia (HA) represents a group of genetically heterogeneous neurodegenerative diseases caused by dysfunction the cerebellum or disruption connection between and other areas central nervous system. Phenotypic manifestation HA includes unsteadiness stance gait, dysarthria, nystagmus, dysmetria complaints clumsiness. There are no specific treatments for HA. Management strategies provide supportive treatment to reduce symptoms. Objectives This systematic review aimed identify, evaluate summarise published literature on therapeutic roles natural remedies in evidence clinical practice. Methods A search was conducted using Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA). Web Science, PubMed Science Direct Scopus were thoroughly searched relevant articles from June 2007 July 2020. Results Ten pre-clinical two studies eligible inclusion this review. We identified medicinal plants Brassica napus, Gardenia jasminoides, Gastrodia elata, Ginkgo biloba, Glycyrrhiza inflata, Paeonia lactiflora, Pueraria lobata Rehmannia glutinosa ; herbal formulations Shaoyao Gancao Tang Zhengan Xifeng Tang; mushroom Hericium erinaceus In review, we evaluated mode actions contributing their effects, including activation ubiquitin–proteasome system, antioxidant pathways, maintenance intracellular calcium homeostasis regulation chaperones. also briefly highlighted integral cellular signalling pathways responsible orchestrating actions. Conclusion reviewed improving halting progression HA, which warrant further study applications into